Learning objectives:

• Understand the biological sources of cell-free DNA
• Recognize the technologies available for cell-free DNA prenatal aneuploidy screening
• Describe the clinical utility of cell-free DNA prenatal aneuploidy screening
• Know the general performance characteristics for cell-free DNA prenatal aneuploidy tests (sensitivity, positive predictive value, etc.)
• Identify challenges associated with cell-free DNA prenatal aneuploidy screening
• Compare cell-free DNA prenatal aneuploidy screening with traditional prenatal screening
• Understand that incidental findings may arise from cell-free DNA prenatal aneuploidy screening
• List future applications of cell-free DNA in prenatal tests