Clinical Immunology

Coronavirus Cytokine Storm

Author information
Lusia Sepiashvili, PhD, DABCC
Melissa R. Snyder, PhD
Drs Sepiashvili and Snyder disclosed no conflict of interest

Learning objectives:

  • Understand the fundamentals of immune response in COVID-19 and the pathophysiologic consequences of cytokine release
  • Define key terminology commonly used in the context of severe COVID-19
  • Identify molecular targets for specific anti-cytokine therapies under investigation in COVID-19
  • Delineate the mechanism of action of tocilizumab
  • Recognize pre-analytical variables and analytical tools that can be used to measure cytokines